Luna 49 is set in the Historic Monuments Zone district of Querétaro, 6.4 km from Queretaro Congress Centre, less than 1 km from San Francisco Temple and a 18-minute walk from Josefa Ortiz de Dominguez Auditorium. The property is located 4.3 km from Autonome University of Querétaro, 4.8 km from Corregidora Stadium and 7.2 km from Metropolitan Theater.
Polytecnic University of Querétaro is 20 km from the guest house. The nearest airport is Querétaro International Airport, 29 km from Luna 49.